The role for gut permeability in the pathogenesis of type 1 diabetes – a solid or leaky concept?. Issue 7 (13th August 2015)

• Record Type: Journal Article
• Authors: Li, Xia; Atkinson, Mark A
• Is Part Of: Pediatric diabetes. Volume 16:Issue 7(2015:Nov.)
• Page Start: 485
• Page End: 492
• Publication Date: 2015-08-13
• Subjects: Diabetes in children -- Periodicals; 616.462
• DOI: 10.1111/pedi.12305
• Languages: English
• ISSNs: 1399-543X

Abstract

<abstract abstract-type="main" id="pedi12305-abs-0001"> <title> <x xml:space="preserve">Abstract</x> </title> <p id="pedi12305-para-0001">Increasing evidence, both functional and morphological, supports the concept of increased intestinal permeability as an intrinsic characteristic of type 1 diabetes (T1D) in both humans and animal models of the disease. Often referred to as a 'leaky gut', its mechanistic impact on the pathogenesis of T1D remains unclear. Hypotheses that this defect influences immune responses against antigens (both self and non‐self) predominate, yet others argue hyperglycemia and insulitis may contribute to increased gut permeability in T1D. To address these complicated issues, we herein review the many conceptual role(s) for a leaky gut in the pathogenesis of T1D and suggest ways that if true, therapeutic interventions aimed at the gut–pancreas axis may prove promising for future therapeutic interventions.</p> </abstract>