Childhood acute lymphoblastic leukemia: Integrating genomics into therapy. Issue 20 (20th July 2015)

• Record Type: Journal Article
• Authors: Tasian, Sarah K.; Loh, Mignon L.; Hunger, Stephen P.
• Is Part Of: Cancer. Volume 121:Issue 20(2015)
• Page Start: 3577
• Page End: 3590
• Publication Date: 2015-07-20
• Subjects: Cancer -- Periodicals; Cancer -- Cytopathology -- Periodicals; 616.99405
• DOI: 10.1002/cncr.29573
• Languages: English
• ISSNs: 0008-543X

Abstract

<abstract abstract-type="main"> <title> <x xml:space="preserve">Abstract</x> </title> <p>Acute lymphoblastic leukemia (ALL), the most common malignancy of childhood, is a genetically complex entity that remains a major cause of childhood cancer‐related mortality. Major advances in genomic and epigenomic profiling during the past decade have appreciably enhanced knowledge of the biology of de novo and relapsed ALL and have facilitated more precise risk stratification of patients. These achievements have also provided critical insights regarding potentially targetable lesions for the development of new therapeutic approaches in the era of precision medicine. In this review, the authors delineate the current genetic landscape of childhood ALL, emphasizing patient outcomes with contemporary treatment regimens as well as therapeutic implications of newly identified genomic alterations in specific subsets of ALL. <bold><italic>Cancer</italic> 2015;121:3577–3590</bold>. © <italic>2015 American Cancer Society</italic>.</p> </abstract>