Nanotheranostics: Congo Red/Rutin‐MNPs with Enhanced Magnetic Resonance Imaging and H2O2‐Responsive Therapy of Alzheimer's Disease in APPswe/PS1dE9 Transgenic Mice. (13th August 2015)

• Record Type: Journal Article
• Authors: Hu, Bingbing; Dai, Fengying; Fan, Zhanming; Ma, Guanghui; Tang, Qunwei; Zhang, Xin
• Is Part Of: Advanced materials. Volume 27:Number 37(2015)
• Page Start: 5499
• Page End: 5505
• Publication Date: 2015-08-13
• Subjects: Materials -- Periodicals; Chemical vapor deposition -- Periodicals; 620.11
• DOI: 10.1002/adma.201502227
• Languages: English
• ISSNs: 0935-9648

Abstract

<abstract abstract-type="graphical" xml:lang="en" id="adma201502227-abs-0001"> <title> <x xml:space="preserve">Abstract</x> </title> <p> <bold>As nanotheranostics, </bold> Congo red/Rutin‐MNPs combine the abilities of diagnosis and treatment of Alzheimer's disease (AD). The biocompatible nanotheranostics system based on iron oxide magnetic nanoparticles, with ultrasmall size and excellent magnetic properties, can specifically detect amyloid plaques by magnetic resonance imaging, realize targeted delivery of AD therapeutic agents, achieve drug controlled release by H₂O₂ response, and prevent oxidative stress. <graphic position="anchor" mimetype="image" xlink:href="ark:/27927/pgk2qg64g7" orientation="portrait" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink" /></p> </abstract>