Nanoparticle‐Loaded Protein–Polymer Nanodroplets for Improved Stability and Conversion Efficiency in Ultrasound Imaging and Drug Delivery. (11th August 2015)

• Record Type: Journal Article
• Authors: Lee, Jeong Yu; Carugo, Dario; Crake, Calum; Owen, Joshua; de Saint Victor, Marie; Seth, Anjali; Coussios, Constantin; Stride, Eleanor
• Is Part Of: Advanced materials. Volume 27:Number 37(2015)
• Page Start: 5484
• Page End: 5492
• Publication Date: 2015-08-11
• Subjects: Materials -- Periodicals; Chemical vapor deposition -- Periodicals; 620.11
• DOI: 10.1002/adma.201502022
• Languages: English
• ISSNs: 0935-9648

Abstract

<abstract abstract-type="graphical" xml:lang="en" id="adma201502022-abs-0001"> <title> <x xml:space="preserve">Abstract</x> </title> <p> <bold>A new formulation of volatile nanodroplets</bold> stabilized by a protein and polymer coating and loaded with magnetic nanoparticles is developed. The droplets show enhanced stability and phase conversion efficiency upon ultrasound exposure compared with existing formulations. Magnetic targeting, encapsulation, and release of an anticancer drug are demonstrated in vitro with a 40% improvement in cytotoxicity compared with free drug. <graphic position="anchor" mimetype="image" xlink:href="ark:/27927/pgk2qg63gr" orientation="portrait" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink" /></p> </abstract>