Synthesis and Analgesic Activity of Annelated Xanthine Derivatives in Experimental Models in Rodents. Issue 10 (6th August 2015)

• Record Type: Journal Article
• Authors: Zygmunt, Małgorzata; Sapa, Jacek; Drabczyńska, Anna; Karcz, Tadeusz; Müller, Christa; Köse, Meryem; Latacz, Gniewomir; Schabikowski, Jakub; Bednarski, Marek; Kieć‐Kononowicz, Katarzyna
• Is Part Of: Archiv der Pharmazie. Volume 348:Issue 10(2015:Oct.)
• Page Start: 704
• Page End: 714
• Publication Date: 2015-08-06
• Subjects: Pharmaceutical chemistry -- Periodicals; Pharmacology -- Periodicals; 615.19
• DOI: 10.1002/ardp.201500169
• Languages: English
• ISSNs: 0365-6233

Abstract

<abstract abstract-type="main" xml:lang="en"> <title> <x xml:space="preserve">Abstract</x> </title> <sec id="ardp201500169-sec-0001" sec-type="section"> <p>A series of annelated derivatives of xanthine were synthesized and assayed as potential analgesic agents. All synthesized xanthine derivatives were tested in the writhing test and hot‐plate test. The pharmacological assays demonstrated that all the compounds prepared, without exception, displayed a significant activity in the mouse writhing assay. The analgesic action of the most active compounds, expressed as ED₅₀ was found to be 1.4–4.3 times more potent than that of acetylsalicylic acid used as the reference compound. However, only some of the compounds demonstrated analgesic activity in the hot‐plate test. The analgesic effect of some compounds is probably related to their agonistic, antagonistic, or partial agonistic activity at the adenosine receptors.</p> </sec> </abstract>