The effect of mode of conception on obstetrical outcomes differs by body mass index. Issue 4 (October 2015)

• Record Type: Journal Article
• Authors: Machtinger, Ronit; Zera, Chloe; Racowsky, Catherine; Missmer, Stacey; Gargiulo, Antonio; Schiff, Eyal; Wilkins-Haug, Louise
• Is Part Of: Reproductive biomedicine online. Volume 31:Issue 4(2015)
• Page Start: 531
• Page End: 537
• Publication Date: 2015-10
• Subjects: Human reproductive technology -- Periodicals; Human embryo -- Periodicals; Reproduction -- Periodicals; 616.692
• DOI: 10.1016/j.rbmo.2015.06.016
• Languages: English
• ISSNs: 1472-6483

Abstract

<abstract abstract-type="author" id="ab0010"> <title id="st0010">Abstract</title> <sec> <p id="sp0010">This study compared the odds of adverse obstetrical outcomes of pregnancies in women who conceived from IVF (<italic>n</italic> = 464) versus spontaneous conception (<italic>n</italic> = 1171) after stratification into three body mass index (BMI) groups: normal weight (18.5–24.9 kg/m²), overweight (25.0–29.9 kg/m²) and obese (&gt;30 kg/m²). With increasing BMI, incidences of complications between IVF and spontaneously conceived groups narrowed. Among women with normal BMI, IVF pregnancies were associated with increased odds of placental ischaemic disorders (11.3% versus 7.0%, adjusted odds ratio [aOR] = 2.24; 95% confidence interval [CI] = 1.25–4.04) and low birthweight &lt;2500 g (10.6% versus 8.0%, aOR = 2.08; 95% CI = 1.12–3.88). Among overweight women, only low birthweight (&lt;2500 g) was significantly increased (15.6% versus 6.2%, aOR = 4.33; 95%, CI = 1.61–11.63). For obese women, there were no differences between IVF and spontaneously conceived pregnancies for either placental ischaemic disorders (12.5 versus 20.2%, OR = 0.43, 95% CI = 0.17–1.1) or low birthweight (10.0% versus 11.0%, aOR = 0.7, 95% CI = 0.24–2.08). Overall, the odds of adverse obstetrical outcomes were not significantly greater in IVF singleton pregnancies compared with those conceived spontaneously as BMI increased.</p> </sec> </abstract>