Emerging Liver–Kidney Interactions in Nonalcoholic Fatty Liver Disease. Issue 10 (October 2015)

• Record Type: Journal Article
• Authors: Musso, Giovanni; Cassader, Maurizio; Cohney, Solomon; Pinach, Silvia; Saba, Francesca; Gambino, Roberto
• Is Part Of: Trends in molecular medicine. Volume 21:Issue 10(2015)
• Page Start: 645
• Page End: 662
• Publication Date: 2015-10
• Subjects: Molecular biology -- Periodicals; Pathology, Molecular -- Periodicals; Physiology, Pathological -- Periodicals; 572.8
• DOI: 10.1016/j.molmed.2015.08.005
• Languages: English
• ISSNs: 1471-4914

Abstract

<abstract abstract-type="author" id="abs0005"> <title> <x xml:space="preserve">Abstract</x> </title> <sec> <p id="spar0005">Mounting evidence connects non-alcoholic fatty liver disease (NAFLD) to chronic kidney disease (CKD). We review emerging mechanistic links between NAFLD and CKD, including altered activation of angiotensin converting enzyme (ACE)-2, nutrient/energy sensors sirtuin-1 and AMP-activated kinase, as well as impaired antioxidant defense mediated by nuclear factor erythroid 2-related factor-2 (Nrf2). Dietary fructose excess may also contribute to NAFLD and CKD. NAFLD affects renal injury through lipoprotein dysmetabolism and altered secretion of the hepatokines fibroblast growth factor-21, fetuin-A, insulin-like growth factor-1, and syndecan-1. CKD may mutually aggravate NAFLD and associated metabolic disturbances through altered intestinal barrier function and microbiota composition, the accumulation of uremic toxic metabolites, and alterations in pre-receptor glucocorticoid metabolism. We conclude by discussing the implications of these findings for the treatment of NAFLD and CKD.</p> </sec> </abstract>