Exhaled Molecular Fingerprinting in Diagnosis and Monitoring: Validating Volatile Promises. Issue 10 (October 2015)

• Record Type: Journal Article
• Authors: Boots, Agnes W.; Bos, Lieuwe D.; van der Schee, Marc P.; van Schooten, Frederik-Jan; Sterk, Peter J.
• Is Part Of: Trends in molecular medicine. Volume 21:Issue 10(2015)
• Page Start: 633
• Page End: 644
• Publication Date: 2015-10
• Subjects: Molecular biology -- Periodicals; Pathology, Molecular -- Periodicals; Physiology, Pathological -- Periodicals; 572.8
• DOI: 10.1016/j.molmed.2015.08.001
• Languages: English
• ISSNs: 1471-4914

Abstract

<abstract abstract-type="author" id="abs0005"> <title> <x xml:space="preserve">Abstract</x> </title> <sec> <p id="spar0005">Medical diagnosis and phenotyping increasingly incorporate information from complex biological samples. This has promoted the development and clinical application of non-invasive metabolomics in exhaled air (breathomics). In respiratory medicine, expired volatile organic compounds (VOCs) are associated with inflammatory, oxidative, microbial, and neoplastic processes. After recent proof of concept studies demonstrating moderate to good diagnostic accuracies, the latest efforts in breathomics are focused on optimization of sensor technologies and analytical algorithms, as well as on independent validation of clinical classification and prediction. Current research strategies are revealing the underlying pathophysiological pathways as well as clinically-acceptable levels of diagnostic accuracy. Implementing recent guidelines on validating molecular signatures in medicine will enhance the clinical potential of breathomics and the development of point-of-care technologies.</p> </sec> </abstract>