Simultaneous determination of ivabradine, metoprolol and their metabolites in rat plasma by ultra-performance liquid chromatography tandem mass spectrometry and its application in a pharmacokinetic study. Issue 19 (7th October 2015)

• Record Type: Journal Article
• Authors: Sun, Wei; Chen, Ruimin; Li, Wanshu; Zhang, Hui; Ye, Jifeng; Cui, Xiao; Huang, Chengke
• Is Part Of: Analytical methods. Volume 7:Issue 19(2015)
• Page Start: 8459
• Page End: 8465
• Publication Date: 2015-10-07
• Subjects: Chemistry, Analytic -- Periodicals; Analytical biochemistry -- Periodicals; Chemical laboratories -- Standards -- Periodicals; 543.1905
• DOI: 10.1039/c5ay01657f
• Languages: English
• ISSNs: 1759-9660

Abstract

<abstract abstract-type="toc"> <title> <x xml:space="preserve">Abstract</x> </title> <p> <graphic position="anchor" id="ga" xlink:href="ark:/27927/pgj2xvksjjq" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink" />A sensitive and rapid UPLC-MS/MS method was developed to determine ivabradine, metoprolol and their corresponding metabolites in rat plasma simultaneously.</p> </abstract>