Molecular hydrogen attenuates hypoxia/reoxygenation injury of intrahepatic cholangiocytes by activating Nrf2 expression. Issue 3 (4th November 2015)

• Record Type: Journal Article
• Authors: Yu, Jianhua; Zhang, Weiguang; Zhang, Rongguo; Jiang, Guixing; Tang, Haijun; Ruan, Xinxian; Ren, Peitu; Lu, Baochun
• Is Part Of: Toxicology letters. Volume 238:Issue 3(2015)
• Page Start: 11
• Page End: 19
• Publication Date: 2015-11-04
• Subjects: Toxicology -- Periodicals; 363.179
• DOI: 10.1016/j.toxlet.2015.08.010
• Languages: English
• ISSNs: 0378-4274

Abstract

<abstract abstract-type="author-highlights" id="abs0005"> <title id="sect0005">Highlights</title> <sec> <p id="spar0025"> <list id="lis0005"> <list-item id="lsti0005"> <label></label> <p id="par0005">H₂ ameliorates cholangiocytes H/R injury <italic>in vitro</italic>.</p> </list-item> <list-item id="lsti0010"> <label></label> <p id="par0010">Nrf2 signaling is activated in cholangiocytes after exposed to H₂.</p> </list-item> <list-item id="lsti0015"> <label></label> <p id="par0015">H₂ could not protect Nrf2-silenced cholangiocytes from H/R injury.</p> </list-item> <list-item id="lsti0020"> <label></label> <p id="par0020">H₂ protects cholangiocytes from I/R injury through <italic>in vivo</italic>.</p> </list-item> </list> </p> </sec> </abstract>