Cyclobutane and Cyclobutene Synthesis: Catalytic Enantioselective [2+2] Cycloadditions. Issue 41 (2nd September 2015)

• Record Type: Journal Article
• Authors: Xu, Yao; Conner, Michael L.; Brown, M. Kevin
• Is Part Of: Angewandte Chemie international edition. Volume 54:Issue 41(2015)
• Page Start: 11918
• Page End: 11928
• Publication Date: 2015-09-02
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1002/anie.201502815
• Languages: English
• ISSNs: 1433-7851

Abstract

<abstract abstract-type="main" xml:lang="en"> <title>Abstract</title> <p>Cyclobutanes and cyclobutenes are important structural motifs found in numerous biologically significant molecules, and they are useful intermediates for chemical synthesis. Consequently, [2+2] cycloadditions to access cyclobutanes and cyclobutenes have been established to be particularly useful transformations. Within the last 10 years, an increase in the frequency of publications for catalytic enantioselective [2+2] cycloadditions has occurred. These reactions provide access to a wide array of enantiomerically enriched chemical diversity that was not previously attainable. Described in this review are the advances made in catalytic enantioselective [2+2] cycloadditions to access cyclobutanes and cyclobutenes.</p> </abstract>