An Environmentally Friendly Method for N‐Methylation of 5‐Substituted 1H‐Tetrazoles with a Green Methylating Reagent: Dimethyl Carbonate. (26th September 2014)

• Record Type: Journal Article
• Authors: Xie, Aming; Zhang, Qiang; Liu, Yangyang; Feng, Liandong; Hu, Xinyu; Dong, Wei
• Is Part Of: Journal of heterocyclic chemistry. Volume 52:Number 5(2015)
• Page Start: 1483
• Page End: 1487
• Publication Date: 2014-09-26
• Subjects: Heterocyclic compounds -- Periodicals; 547.59
• DOI: 10.1002/jhet.2179
• Languages: English
• ISSNs: 0022-152X

Abstract

<abstract abstract-type="main"> <title> <x xml:space="preserve">Abstract</x> </title> <p>An environmentally friendly method was established for the <named-content content-type="reactionType" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink"><italic>N</italic>‐methylation</named-content> of the 5‐substituted 1<italic>H</italic>‐tetrazoles with a green reagent: DMC. DABCO was the optimal catalyst, and hazardous chemicals were avoided in this protocol. A plausible catalytic mechanism is proposed, which consists of a DABCO‐activated process and a thermally induced <named-content content-type="reactionType" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink">rearrangement</named-content> of tetrazole carbamates.</p> </abstract>