Increased CD38 expression on T lymphocytes as a marker of HIV dissemination into the central nervous system. Issue 5 (October 2015)

• Record Type: Journal Article
• Authors: Dentone, Chiara; Fenoglio, Daniela; Schenone, Eva; Cenderello, Giovanni; Prinapori, Roberta; Signori, Alessio; Parodi, Alessia; Kalli, Francesca; Battaglia, Florinda; Feasi, Marcello; Bruzzone, Bianca; Viscoli, Claudio; Filaci, Gilberto; Di Biagio, Antonio
• Is Part Of: HIV clinical trials. Volume 16:Issue 5(2015)
• Page Start: 190
• Page End: 196
• Publication Date: 2015-10
• Subjects: HIV Infections -- Chemotherapy -- Periodicals; AIDS (Disease) -- Chemotherapy -- Periodicals; HIV Infections -- Research -- Periodicals; AIDS (Disease) -- Research -- Periodicals; 616.979206105
• DOI: 10.1179/1945577115Y.0000000005
• Languages: German
• ISSNs: 1528-4336

Abstract

<abstract> <title> <x content-type="archive" xml:space="preserve">Abstract</x> </title> <p>Cross-sectional analysis on 20 HIV-1 patients with neurological symptoms admitted to two infectious disease units. Cut-off of HIV–RNA (VL) was 20 copies/ml for plasma and cerebral spinal fluid (CSF). Flow cytometry was used to analyze the phenotype of circulating and CSF T lymphocytes. CD38 mean fluorescence intensity (MFI) was higher on circulating CD4<sup>+</sup>T lymphocytes from patients with VL >20 copies/ml in plasma (<italic>P</italic> = 0.001) or CSF (<italic>P</italic> = 0.001). The frequency of circulating CD8<sup>+</sup>CD38<sup>+</sup>T cells and CD38 MFI on these cells were higher in patients with VL >20 copies/ml than in those with undetectable plasma VL (<italic>P</italic> = 0.030 and <italic>P</italic> = 0.023). The frequency of CSF CD4<sup>+</sup>CD38<sup>+</sup>T, as well as their CD38 and CD95 MFI, were increased in patients with detectable than non-detectable plasma VL (<italic>P</italic> = 0.01, <italic>P</italic> = 0.03, and <italic>P</italic> = 0.05). The % CD38<sup>+</sup>CD8<sup>+</sup>T in CSF correlated with time of virological suppression (ρ = − 0.462, <italic>P</italic> = 0.040) and the CNS penetration-effectiveness (CPE) score (ρ = − 0.467, <italic>P</italic> = 0.038). In conclusion, (a) the expression of CD38<sup>+</sup> on both CD4<sup>+</sup>, CD8<sup>+</sup>T lymphocytes from peripheral blood and CSF discriminated between viremic and non-viremic patients and (b) T cell activation/apoptosis markers inversely correlated with CPE to remark the importance for therapy to restore immunological functions.</p> </abstract>