There is Kisspeptin – And Then There is Kisspeptin. (October 2015)

• Record Type: Journal Article
• Authors: Hussain, Mehboob A.; Song, Woo-Jin; Wolfe, Andrew
• Is Part Of: Trends in endocrinology and metabolism. Volume 26:Number 10(2015)
• Page Start: 564
• Page End: 572
• Publication Date: 2015-10
• Subjects: Endocrinology -- Periodicals; Metabolism -- Periodicals; Metabolism; 616.4
• DOI: 10.1016/j.tem.2015.07.008
• Languages: English
• ISSNs: 1043-2760

Abstract

<abstract abstract-type="author" id="abs0005"> <title> <x xml:space="preserve">Abstract</x> </title> <sec> <p id="spar0005">While kisspeptin was initially found to function as a metastasis suppressor, after identification of its receptor KISS1R and their expression profiles in tissues such as the hypothalamus and adrenals, kisspeptin and KISS1R were predominantly assigned endocrine functions, including regulating puberty and fertility through their actions on hypothalamic gonadotropin releasing hormone production. More recently, an alter ego for kisspeptin has emerged, with a significant role in regulating glucose homeostasis, insulin secretion, as well as food intake and body composition, and deficient kisspeptin signaling results in reduced locomotor activity and increased adiposity. This review highlights these recent observations on the role of kisspeptin in metabolism as well as several key questions that need to be addressed in the future.</p> </sec> </abstract>