Classification of neurological abnormalities in children with congenital melanocytic naevus syndrome identifies magnetic resonance imaging as the best predictor of clinical outcome. (27th August 2015)

• Record Type: Journal Article
• Authors: Waelchli, R.; Aylett, S.E.; Atherton, D.; Thompson, D.J.; Chong, W.K.; Kinsler, V.A.
• Is Part Of: British journal of dermatology. Volume 173:Number 3(2015:Sep.)
• Page Start: 739
• Page End: 750
• Publication Date: 2015-08-27
• Subjects: Dermatology -- Periodicals; Skin -- Diseases -- Periodicals; 616.5
• DOI: 10.1111/bjd.13898
• Languages: English
• ISSNs: 0007-0963

Abstract

<abstract abstract-type="short" xml:lang="en" id="bjd13898-abs-0002"> <title> <x xml:space="preserve">Abstract</x> </title> <p> <bold>What's already known about this topic?</bold> </p> <p> <list id="bjd13898-list-0001" list-type="bullet"> <list-item> <p>Multiple congenital melanocytic naevi (CMN; more than one lesion at birth) can be associated with abnormalities of the central nervous system (CNS). The spectrum of these abnormalities includes congenital and acquired pathologies, melanotic and nonmelanotic lesions, rendering the term 'CMN syndrome' more appropriate than 'neurocutaneous melanosis'.</p> </list-item> <list-item> <p>Symptomatic CNS abnormalities were previously thought to carry a universally poor prognosis, although cohort data in the last decade have argued against this.</p> </list-item> </list> </p> <p> <bold>What does this study add?</bold> </p> <p> <list id="bjd13898-list-0002" list-type="bullet"> <list-item> <p>A single CNS magnetic resonance imaging scan in multiple CMN, independent of projected adult size or site of the largest naevus, and ideally in the first 6 months of life, is currently an appropriate screening strategy.</p> </list-item> <list-item> <p>An abnormal result is a better statistical predictor of clinical outcome than cutaneous phenotype.</p> </list-item> <list-item> <p>Clinical management is altered as a result of the radiological result.</p> </list-item> </list> </p> </abstract>