2-Litre polyethylene glycol-citrate-simethicone plus bisacodyl versus 4-litre polyethylene glycol as preparation for colonoscopy in chronic constipation. Issue 10 (October 2015)

• Record Type: Journal Article
• Authors: Parente, Fabrizio; Vailati, Cristian; Bargiggia, Stefano; Manes, Gianpiero; Fontana, Paola; Masci, Enzo; Arena, Monica; Spinzi, Giancarlo; Baccarin, Alessandra; Mazzoleni, Giorgia; Testoni, Pier Alberto
• Is Part Of: Digestive and liver disease. Volume 47:Issue 10(2015)
• Page Start: 857
• Page End: 863
• Publication Date: 2015-10
• Subjects: Digestive organs -- Diseases -- Periodicals; Liver -- Diseases -- Periodicals; 616.33005
• DOI: 10.1016/j.dld.2015.06.008
• Languages: English
• ISSNs: 1590-8658

Abstract

<abstract abstract-type="author" id="abs0005"> <title id="sect0005">Abstract</title> <sec> <title id="sect0010">Background</title> <p id="spar0005">Chronic constipation is a risk factor of inadequate bowel preparation for colonoscopy; however, no large clinical trials have been performed in this subgroup of patients.</p> </sec> <sec> <title id="sect0015">Aims</title> <p id="spar0010">To compare bowel cleansing efficacy, tolerability and acceptability of 2-L polyethylene-glycol-citrate-simethicone (PEG-CS) plus 2-day bisacodyl (reinforced regimen) vs. 4-L PEG in patients with chronic constipation undergoing colonoscopy.</p> </sec> <sec> <title id="sect0020">Methods</title> <p id="spar0015">Randomized, observer-blind, parallel group study. Adult outpatients undergoing colonoscopy were randomly allocated to 2-L PEG-CS/bisacodyl or 4-L PEG, taken as split regimens before colonoscopy. Quality of bowel preparation was assessed by the Ottawa Bowel Cleansing Scale (OBCS). The amount of foam/bubble interfering with colonic visualization was also measured.</p> </sec> <sec> <title id="sect0025">Results</title> <p id="spar0020">400 patients were enrolled. There was no significant difference in successful cleansing (OBCS score ≤6): 80.2% in the 2-L PEG-CS/bisacodyl vs. 81.4% in the 4-L PEG group. Significantly more patients taking 2L PEG-CS/bisacodyl showed no or minimal foam/bubbles in all colonic segments (80% vs. 63%; <italic>p</italic> < 0.001). 2-L PEG-CS/bisacodyl was significantly more acceptable for ease of administration (<italic>p</italic> < 0.001), willingness to repeat (<italic>p</italic> < 0.001) and showed better compliance (<italic>p</italic> = 0.002).</p> </sec> <sec> <title id="sect0030">Conclusion</title> <p id="spar0025">Split 2-L PEG-CS plus bisacodyl was not superior to split 4-L PEG for colonoscopy bowel cleansing in patients with chronic constipation; however, it performed better than the standard regimen in terms of colonic mucosa visualization, patient acceptance and compliance.</p> </sec> </abstract>