Mechanistic investigation of aziridine aldehyde-driven peptide macrocyclization: the imidoanhydride pathway1. Issue 10 (14th October 2015)

• Record Type: Journal Article
• Authors: Zaretsky, Serge; Hickey, Jennifer L.; Tan, Joanne; Pichugin, Dmitry; St. Denis, Megan A.; Ler, Spencer; Chung, Benjamin K. W.; Scully, Conor C. G.; Yudin, Andrei K.
• Is Part Of: Chemical science. Volume 6:Issue 10(2015:Oct.)
• Page Start: 5446
• Page End: 5455
• Publication Date: 2015-10-14
• Subjects: Chemistry -- Periodicals; 540.5
• DOI: 10.1039/c5sc01958c
• Languages: English
• ISSNs: 2041-6520

Abstract

<abstract abstract-type="toc"> <title> <x xml:space="preserve">Abstract</x> </title> <p> <graphic position="anchor" id="ga" xlink:href="ark:/27927/pgj2qs2zj9f" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink" />Aziridine aldehydes participate in a multicomponent reaction with α-amino amides and isocyanides to generate reactive imidoanhydride intermediates.</p> </abstract>