Fulminant skin GvHD with a cytokine pattern resemblant of cytokine release syndrome successfully treated with multimodal immunosuppression including tocilizumab. Issue 11 (7th July 2015)

• Record Type: Journal Article
• Authors: Hellwig, Yuliya; Yoo, Young E.; Reß, Marie L.; Andres, Oliver; Braun, Matthias; Schlegel, Paul G.; Wölfl, Matthias
• Is Part Of: Pediatric blood & cancer. Volume 62:Issue 11(2015:Nov.)
• Page Start: 2033
• Page End: 2035
• Publication Date: 2015-07-07
• Subjects: Tumors in children -- Periodicals; Blood -- Diseases -- Periodicals; Cancer in children -- Periodicals; 618.92
• DOI: 10.1002/pbc.25595
• Languages: English
• ISSNs: 1545-5009

Abstract

<abstract abstract-type="main" xml:lang="en"> <title> <x xml:space="preserve">Abstract</x> </title> <sec id="pbc25595-sec-0001" sec-type="section"> <p>Acute Graft‐versus‐Host‐Disease (GvHD) is a potentially life‐threatening complication after allogeneic stem cell transplantation. If not treated early and adequately, the complex immunological mechanisms may lead to a self‐perpetuating cycle of alloreactivity, which is then associated with a high mortality. Here we assessed the cytokine profile on a daily basis in a patient with grade 4 skin GvHD, demonstrating a signature resembling cytokine‐release‐syndrome. After multimodal immunosuppressive intervention, including treatment with the IL6 receptor‐blocking antibody tocilizumab, the severe clinical symptoms unexpectedly resolved within 48hr. Pediatr Blood Cancer © 2015 Wiley Periodicals, Inc.</p> </sec> </abstract>