A dual optical and nuclear imaging reagent for peptide labelling via disulfide bridging1. Issue 37 (7th October 2015)

• Record Type: Journal Article
• Authors: Fletcher, Sally A.; Sin, Pak Kwan Brian; Nobles, Muriel; Årstad, Erik; Tinker, Andrew; Baker, James R.
• Is Part Of: Organic & biomolecular chemistry. Volume 13:Issue 37(2015)
• Page Start: 9559
• Page End: 9563
• Publication Date: 2015-10-07
• Subjects: Chemistry, Organic -- Periodicals; Bioorganic chemistry -- Periodicals; Chemistry, Physical organic -- Periodicals; 547
• DOI: 10.1039/c5ob01468a
• Languages: English
• ISSNs: 1477-0520

Abstract

<abstract abstract-type="toc"> <title> <x xml:space="preserve">Abstract</x> </title> <p> <graphic position="anchor" id="ga" xlink:href="ark:/27927/pgj2qrn7nzj" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink" />We report a concise approach to a multimodal imaging reagent for peptide labelling <italic>via</italic> disulfide bridging. The reagent is constructed using a one pot, three component, [3 + 2] cycloaddition of a fluorescent azide with a dithiomaleimide-alkyne, with concomitant incorporation of ¹²⁵I.</p> </abstract>