Screening of quinoline, 1, 3-benzoxazine, and 1, 3-oxazine-based small molecules against isolated methionyl-tRNA synthetase and A549 and HCT116 cancer cells including an in silico binding mode analysis1. Issue 36 (28th September 2015)

• Record Type: Journal Article
• Authors: Bharathkumar, Hanumantharayappa; Mohan, Chakrabhavi Dhananjaya; Rangappa, Shobith; Kang, Taehee; Keerthy, H. K.; Fuchs, Julian E.; Kwon, Nam Hoon; Bender, Andreas; Kim, Sunghoon; Basappa; Rangappa, Kanchugarakoppal S.
• Is Part Of: Organic & biomolecular chemistry. Volume 13:Issue 36(2015)
• Page Start: 9381
• Page End: 9387
• Publication Date: 2015-09-28
• Subjects: Chemistry, Organic -- Periodicals; Bioorganic chemistry -- Periodicals; Chemistry, Physical organic -- Periodicals; 547
• DOI: 10.1039/c5ob00791g
• Languages: English
• ISSNs: 1477-0520

Abstract

<abstract abstract-type="toc"> <title> <x xml:space="preserve">Abstract</x> </title> <p> <graphic position="anchor" id="ga" xlink:href="ark:/27927/pgj2qrn2rdv" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink" />Elevated activity of methionyl-tRNA synthetase (MRS) in many cancers renders it a possible drug target in this disease area, as well as in a series of parasitic diseases.</p> </abstract>