Effects of structural modifications on the metal binding, anti-amyloid activity, and cholinesterase inhibitory activity of chalcones1. Issue 36 (28th September 2015)

• Record Type: Journal Article
• Authors: Fosso, Marina Y.; LeVine 3rd, Harry; Green, Keith D.; Tsodikov, Oleg V.; Garneau-Tsodikova, Sylvie
• Is Part Of: Organic & biomolecular chemistry. Volume 13:Issue 36(2015)
• Page Start: 9418
• Page End: 9426
• Publication Date: 2015-09-28
• Subjects: Chemistry, Organic -- Periodicals; Bioorganic chemistry -- Periodicals; Chemistry, Physical organic -- Periodicals; 547
• DOI: 10.1039/c5ob01478f
• Languages: English
• ISSNs: 1477-0520

Abstract

<abstract abstract-type="toc"> <title> <x xml:space="preserve">Abstract</x> </title> <p> <graphic position="anchor" id="ga" xlink:href="ark:/27927/pgj2qrn2tdw" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink" />Twenty chalcone derivatives were synthesized and found to bind Cu²⁺ and Zn²⁺ ions, modulate the dissociation of Aβ aggregates, and inhibit acetylcholinesterase activity. These chalcones show promise for the development of probes and/or therapeutics for Alzheimer's disease.</p> </abstract>