A passive-flow microfluidic device for imaging latent HIV activation dynamics in single T cells1. Issue 9 (1st September 2015)

• Record Type: Journal Article
• Authors: Ramji, Ramesh; Wong, Victor C.; Chavali, Arvind K.; Gearhart, Larisa M.; Miller-Jensen, Kathryn
• Is Part Of: Integrative biology. Volume 7:Issue 9(2015:Sep.)
• Page Start: 998
• Page End: 1010
• Publication Date: 2015-09-01
• Subjects: Biology -- Periodicals; Technology -- Periodicals; Biological systems -- Periodicals; 570.5
• DOI: 10.1039/c5ib00094g
• Languages: English
• ISSNs: 1757-9694

Abstract

<abstract abstract-type="toc"> <title> <x xml:space="preserve">Abstract</x> </title> <p> <graphic position="anchor" id="ga" xlink:href="ark:/27927/pgj2qrmfpwd" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink" />We designed a passive-flow microfluidic device to image HIV activation dynamics in live individual T cells. We show that drugs that activate transcription factors stimulate latent HIV with distinct noise profiles from drugs that inhibit chromatin remodeling proteins.</p> </abstract>