Quality of life (QoL) and International Normalized Ratio (INR) control of patients attending anticoagulation clinics. Issue 7 (July 2015)

• Record Type: Journal Article
• Authors: Hasan, S.S.; Teh, K.M.; Ahmed, S.I.; Chong, D.W.K.; Ong, H.C.; Naina, B.
• Is Part Of: Public health. Volume 129:Issue 7(2015:Jul.)
• Page Start: 954
• Page End: 962
• Publication Date: 2015-07
• Subjects: Public health -- Periodicals; Public health -- Periodicals; Electronic journals; 362.1
• DOI: 10.1016/j.puhe.2015.05.014
• Languages: English
• ISSNs: 0033-3506

Abstract

<abstract xml:lang="en" abstract-type="author" id="abs0010"> <title id="sectitle0010">Abstract</title> <sec> <title id="sectitle0015">Objectives</title> <p id="abspara0010">To investigate association between quality of life (QoL) and International Normalized Ratio (INR) control, with the secondary aim of assessing QoL using generic and anticoagulation-specific, the Short Form Health Survey (SF-12) and the Duke Anticoagulation Satisfaction Scale (DASS).</p> </sec> <sec> <title id="sectitle0020">Study design</title> <p id="abspara0015">This study assessed anticoagulation related QoL at three time intervals in two groups of patients on long-term warfarin therapy.</p> </sec> <sec> <title id="sectitle0025">Methods</title> <p id="abspara0020">Data of 326 randomly sampled patients (163 patients each in DASS and SF-12 groups) who had been on warfarin therapy for at least one year at anticoagulation clinics were analysed. QoL was assessed at three time intervals: at the start, six months and one year of warfarin therapy. Indications and target INR ranges and subjects INR values were recorded. Time in Therapeutic Range (TTR) was estimated for four subject subgroups, based on target ranges of INR for clustered indications.</p> </sec> <sec> <title id="sectitle0030">Results</title> <p id="abspara0025">Of the total, 43% of the subjects were aged between 50 and 64 years, and 51% were female. DASS assessed subjects older than 35 years perceived significant decrease in overall mean scores of anticoagulation related QoL, whilst all SF-12 assessed subjects perceived an increase in QoL. The mean percentage days in range for all INR target range subgroups did not exceed more than 60% but there was only a weak correlation (Rs = 0.104, <italic>P</italic> > 0.05) between INR control and overall QoL.</p> </sec> <sec> <title id="sectitle0035">Conclusion</title> <p id="abspara0030">Malaysian urban outpatients on warfarin treatment longer than one year report a significant overall decrease in QoL, as measured using a validated condition-specific instrument. These patients appeared to adapt well to lifestyle limitations imposed by long-term anticoagulation.</p> </sec> </abstract>