Dual Catalysis for the Redox Annulation of Nitroalkynes with Indoles: Enantioselective Construction of Indolin‐3‐ones Bearing Quaternary Stereocenters. Issue 38 (5th August 2015)

• Record Type: Journal Article
• Authors: Liu, Ren‐Rong; Ye, Shi‐Chun; Lu, Chuan‐Jun; Zhuang, Gui‐Lin; Gao, Jian‐Rong; Jia, Yi‐Xia
• Is Part Of: Angewandte Chemie international edition. Volume 54:Issue 38(2015)
• Page Start: 11205
• Page End: 11208
• Publication Date: 2015-08-05
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1002/anie.201504697
• Languages: English
• ISSNs: 1433-7851

Abstract

<abstract abstract-type="main" xml:lang="en"> <title>Abstract</title> <p>The enantioselective redox annulation of nitroalkynes with indoles is enabled by gold/chiral phosphoric acid dual catalysis. A range of indolin‐3‐one derivatives bearing quaternary stereocenters at the C2 position were afforded in good yields and excellent enantioselectivities (up to 96 % <italic>ee</italic>) from readily available starting materials.</p> </abstract>