Inhibition of human cytochrome P450 enzymes by licochalcone A, a naturally occurring constituent of licorice. Issue 7 (October 2015)

• Record Type: Journal Article
• Authors: He, Wei; Wu, Jing-Jing; Ning, Jing; Hou, Jie; Xin, Hong; He, Yu-Qi; Ge, Guang-Bo; Xu, Wei
• Is Part Of: Toxicology in vitro. Volume 29:Issue 7(2015)
• Page Start: 1569
• Page End: 1576
• Publication Date: 2015-10
• Subjects: Toxicity testing -- In vitro -- Periodicals; Toxicology -- Periodicals; 615.9
• DOI: 10.1016/j.tiv.2015.06.014
• Languages: English
• ISSNs: 0887-2333

Abstract

<abstract xml:lang="en" abstract-type="author-highlights" id="ab005"> <title id="st005">Highlights</title> <sec> <p id="sp0005"> <list id="l0005"> <list-item id="o0005"> <label></label> <p id="p0005">Licochalcone A (LCA) could strongly inhibit CYP1A2, 2C19, 2C8, 2C9 and 3A4.</p> </list-item> <list-item id="o0010"> <label></label> <p id="p0010">LCA caused mixed-type inhibition against CYP1A2, 2C9, 2C19 and 2C8.</p> </list-item> <list-item id="o0015"> <label></label> <p id="p0015">LCA was a competitive inhibitor towards CYP3A4.</p> </list-item> <list-item id="o0020"> <label></label> <p id="p0020">The predictions of <italic>in vivo</italic> herb–drug interactions were performed based on the <italic>in vitro</italic> data.</p> </list-item> </list> </p> </sec> </abstract>