Different mechanisms are involved in oxidative DNA damage and genotoxicity induction by ZnO and TiO2 nanoparticles in human colon carcinoma cells. Issue 7 (October 2015)

• Record Type: Journal Article
• Authors: Zijno, Andrea; De Angelis, Isabella; De Berardis, Barbara; Andreoli, Cristina; Russo, Maria Teresa; Pietraforte, Donatella; Scorza, Giuseppe; Degan, Paolo; Ponti, Jessica; Rossi, Francois; Barone, Flavia
• Is Part Of: Toxicology in vitro. Volume 29:Issue 7(2015)
• Page Start: 1503
• Page End: 1512
• Publication Date: 2015-10
• Subjects: Toxicity testing -- In vitro -- Periodicals; Toxicology -- Periodicals; 615.9
• DOI: 10.1016/j.tiv.2015.06.009
• Languages: English
• ISSNs: 0887-2333

Abstract

<abstract xml:lang="en" abstract-type="author-highlights" id="ab005"> <title id="st005">Highlights</title> <sec> <p id="sp0005"> <list id="l0005"> <list-item id="o0005"> <label></label> <p id="p0005">We compared ZnO and TiO₂ nanoparticle genotoxic potential in relation to oxidative stress.</p> </list-item> <list-item id="o0010"> <label></label> <p id="p0010">Multiple endpoints for genotoxic detection were analyzed on Caco-2 cells.</p> </list-item> <list-item id="o0015"> <label></label> <p id="p0015">Both nanoparticles were able to induce ROS and 8-oxodG.</p> </list-item> <list-item id="o0020"> <label></label> <p id="p0020">Oxidative DNA damage was efficiently repaired only after treatment with TiO₂ nanoparticles.</p> </list-item> <list-item id="o0025"> <label></label> <p id="p0025">Only ZnO nanoparticles induced micronuclei.</p> </list-item> </list> </p> </sec> </abstract>