Acute myeloid leukemia cells MOLM-13 and SKM-1 established for resistance by azacytidine are crossresistant to P-glycoprotein substrates. Issue 7 (October 2015)

• Record Type: Journal Article
• Authors: Messingerova, Lucia; Imrichova, Denisa; Kavcova, Helena; Turakova, Katarina; Breier, Albert; Sulova, Zdena
• Is Part Of: Toxicology in vitro. Volume 29:Issue 7(2015)
• Page Start: 1405
• Page End: 1415
• Publication Date: 2015-10
• Subjects: Toxicity testing -- In vitro -- Periodicals; Toxicology -- Periodicals; 615.9
• DOI: 10.1016/j.tiv.2015.05.011
• Languages: English
• ISSNs: 0887-2333

Abstract

<abstract xml:lang="en" abstract-type="author-highlights" id="ab005"> <title id="st005">Highlights</title> <sec> <p id="sp0005"> <list id="l0005"> <list-item id="o0005"> <label></label> <p id="p0005">Multidrug resistant SKM-1 and MOLM-13 cell variants by selection with azacytidine were established.</p> </list-item> <list-item id="o0010"> <label></label> <p id="p0010">Induction of P-glycoprotein and glutathione S-transferase in resistant cell variants were proved.</p> </list-item> <list-item id="o0015"> <label></label> <p id="p0015">Altered expressions of antiapoptotic and proapoptotic proteins in resistant variant of cells were observed.</p> </list-item> <list-item id="o0020"> <label></label> <p id="p0020">Resistant variants of SKM-1 and MOLM-13 cells exert depressed sensitivity to AzaC and P-gp substrates.</p> </list-item> </list> </p> </sec> </abstract>