Basal efflux of bile acids contributes to drug-induced bile acid-dependent hepatocyte toxicity in rat sandwich-cultured hepatocytes. Issue 7 (October 2015)

• Record Type: Journal Article
• Authors: Susukida, Takeshi; Sekine, Shuichi; Ogimura, Eiichiro; Aoki, Shigeki; Oizumi, Kumiko; Horie, Toshiharu; Ito, Kousei
• Is Part Of: Toxicology in vitro. Volume 29:Issue 7(2015)
• Page Start: 1454
• Page End: 1463
• Publication Date: 2015-10
• Subjects: Toxicity testing -- In vitro -- Periodicals; Toxicology -- Periodicals; 615.9
• DOI: 10.1016/j.tiv.2015.06.004
• Languages: English
• ISSNs: 0887-2333

Abstract

<abstract xml:lang="en" abstract-type="author-highlights" id="ab005"> <title id="st005">Highlights</title> <sec> <p id="sp0005"> <list id="l0005"> <list-item id="o0005"> <label></label> <p id="p0005">Accumulation of bile acids in hepatocytes is a mechanism of cholestatic liver injury.</p> </list-item> <list-item id="o0010"> <label></label> <p id="p0010">Sandwich cultured hepatocytes was used to evaluate cholestatic drugs <italic>in vitro</italic>.</p> </list-item> <list-item id="o0015"> <label></label> <p id="p0015">Some basal efflux transporters are known to participate in bile acids efflux.</p> </list-item> <list-item id="o0020"> <label></label> <p id="p0020">Inhibition of basal bile acids efflux by test drugs exacerbated hepatocyte toxicity.</p> </list-item> <list-item id="o0025"> <label></label> <p id="p0025">Basal efflux of bile acids contributes to bile acid-dependent hepatocyte toxicity.</p> </list-item> </list> </p> </sec> </abstract>