Lipoic acid and N-acetylcysteine prevent ammonia-induced inflammatory response in C6 astroglial cells: The putative role of ERK and HO1 signaling pathways. Issue 7 (October 2015)

• Record Type: Journal Article
• Authors: Santos, Camila Leite; Bobermin, Larissa Daniele; Souza, Débora Guerini; Bellaver, Bruna; Bellaver, Gabriela; Arús, Bernardo Assein; Souza, Diogo Onofre; Gonçalves, Carlos-Alberto; Quincozes-Santos, André
• Is Part Of: Toxicology in vitro. Volume 29:Issue 7(2015)
• Page Start: 1350
• Page End: 1357
• Publication Date: 2015-10
• Subjects: Toxicity testing -- In vitro -- Periodicals; Toxicology -- Periodicals; 615.9
• DOI: 10.1016/j.tiv.2015.05.023
• Languages: English
• ISSNs: 0887-2333

Abstract

<abstract xml:lang="en" abstract-type="author-highlights" id="ab005"> <title id="st005">Highlights</title> <sec> <p id="sp0005"> <list id="l0005"> <list-item id="o0005"> <label></label> <p id="p0005">Ammonia toxicity induces GSH depletion.</p> </list-item> <list-item id="o0010"> <label></label> <p id="p0010">Ammonia stimulates cytokine release and transcriptional activity of NFκB.</p> </list-item> <list-item id="o0015"> <label></label> <p id="p0015">LA and NAC are proposed to protect C6 astroglial cells.</p> </list-item> <list-item id="o0020"> <label></label> <p id="p0020">LA and NAC prevent ammonia-induced inflammatory response through ERK and HO1 pathways.</p> </list-item> </list> </p> </sec> </abstract>