Methylglyoxal, a reactive glucose metabolite, enhances autophagy flux and suppresses proliferation of human retinal pigment epithelial ARPE-19 cells. Issue 7 (October 2015)

• Record Type: Journal Article
• Authors: Chang, Yo-Chen; Hsieh, Ming-Chu; Wu, Horng-Jiun; Wu, Wen-Chuan; Kao, Ying-Hsien
• Is Part Of: Toxicology in vitro. Volume 29:Issue 7(2015)
• Page Start: 1358
• Page End: 1368
• Publication Date: 2015-10
• Subjects: Toxicity testing -- In vitro -- Periodicals; Toxicology -- Periodicals; 615.9
• DOI: 10.1016/j.tiv.2015.05.014
• Languages: English
• ISSNs: 0887-2333

Abstract

<abstract xml:lang="en" abstract-type="author-highlights" id="ab005"> <title id="st005">Highlights</title> <sec> <p id="sp0005"> <list id="l0005"> <list-item id="o0005"> <label></label> <p id="p0005">MGO suppresses ARPE-19 cell growth and potentiates H₂O₂-induced cytotoxicity.</p> </list-item> <list-item id="o0010"> <label></label> <p id="p0010">MGO enhances autophagy flux and autophagosome accumulation in ARPE-19 cells.</p> </list-item> <list-item id="o0015"> <label></label> <p id="p0015">Akt and MAPK signaling pathways are involved in MGO-elicited effect.</p> </list-item> <list-item id="o0020"> <label></label> <p id="p0020">Autophagy and kinase inhibitors ameliorate MGO-suppressed RPE cell growth.</p> </list-item> <list-item id="o0025"> <label></label> <p id="p0025">Autophagy and kinase inhibitors might be a therapeutic modality for AMD.</p> </list-item> </list> </p> </sec> </abstract>