Detection and measurement of the agonistic activities of PCBs and mono-hydroxylated PCBs to the constitutive androstane receptor using a recombinant yeast assay. Issue 7 (October 2015)

• Record Type: Journal Article
• Authors: Kamata, Ryo; Shiraishi, Fujio; Kageyama, Shiho; Nakajima, Daisuke
• Is Part Of: Toxicology in vitro. Volume 29:Issue 7(2015)
• Page Start: 1859
• Page End: 1867
• Publication Date: 2015-10
• Subjects: Toxicity testing -- In vitro -- Periodicals; Toxicology -- Periodicals; 615.9
• DOI: 10.1016/j.tiv.2015.07.021
• Languages: English
• ISSNs: 0887-2333

Abstract

<abstract xml:lang="en" abstract-type="author-highlights" id="ab005"> <title id="st005">Highlights</title> <sec> <p id="sp0005"> <list id="l0005"> <list-item id="o0005"> <label></label> <p id="p0005">PCBs and OH-PCBs were tested for their ability to activate the CAR.</p> </list-item> <list-item id="o0010"> <label></label> <p id="p0010">Most of the tested PCBs and OH-PCBs activated CAR-mediated transcription.</p> </list-item> <list-item id="o0015"> <label></label> <p id="p0015">The CAR activities of the PCBs were greatly changed by presence of a hydroxyl group.</p> </list-item> <list-item id="o0020"> <label></label> <p id="p0020">Several OH-PCBs were much more potent than their non-hydroxylated analogs.</p> </list-item> </list> </p> </sec> </abstract>