4-Nonylphenol reduces cell viability and induces apoptosis and ER-stress in a human epithelial intestinal cell line. Issue 7 (October 2015)

• Record Type: Journal Article
• Authors: Lepretti, M.; Paolella, G.; Giordano, D.; Marabotti, A.; Gay, F.; Capaldo, A.; Esposito, C.; Caputo, I.
• Is Part Of: Toxicology in vitro. Volume 29:Issue 7(2015)
• Page Start: 1436
• Page End: 1444
• Publication Date: 2015-10
• Subjects: Toxicity testing -- In vitro -- Periodicals; Toxicology -- Periodicals; 615.9
• DOI: 10.1016/j.tiv.2015.04.022
• Languages: English
• ISSNs: 0887-2333

Abstract

<abstract xml:lang="en" abstract-type="author-highlights" id="ab005"> <title id="st005">Highlights</title> <sec> <p id="sp0005"> <list id="l0005"> <list-item id="o0005"> <label></label> <p id="p0005">The surfactant 4-nonylphenol (4-NP) is a common food contaminant.</p> </list-item> <list-item id="o0010"> <label></label> <p id="p0010">4-NP is cytotoxic for undifferentiated human intestinal Caco-2 cells.</p> </list-item> <list-item id="o0015"> <label></label> <p id="p0015">4-NP displays anti-proliferative effects and interferes with EGF signalling.</p> </list-item> <list-item id="o0020"> <label></label> <p id="p0020">4-NP induces cell apoptosis and triggers an ER-stress response.</p> </list-item> <list-item id="o0025"> <label></label> <p id="p0025">A daily intake of 4-NP-containing food may have harmful effects on human intestine.</p> </list-item> </list> </p> </sec> </abstract>