Evaluation of an air–liquid interface cell culture model for studies on the inflammatory and cytotoxic responses to tobacco smoke aerosols. Issue 7 (October 2015)

• Record Type: Journal Article
• Authors: Azzopardi, David; Haswell, Linsey E.; Foss-Smith, Geoff; Hewitt, Katherine; Asquith, Nathan; Corke, Sarah; Phillips, Gary
• Is Part Of: Toxicology in vitro. Volume 29:Issue 7(2015)
• Page Start: 1720
• Page End: 1728
• Publication Date: 2015-10
• Subjects: Toxicity testing -- In vitro -- Periodicals; Toxicology -- Periodicals; 615.9
• DOI: 10.1016/j.tiv.2015.06.016
• Languages: English
• ISSNs: 0887-2333

Abstract

<abstract xml:lang="en" abstract-type="author-highlights" id="ab005"> <title id="st005">Highlights</title> <sec> <p id="sp0005"> <list id="l0005"> <list-item id="o0005"> <label></label> <p id="p0005">Tobacco smoke induces cytotoxicity and an inflammatory response in NCI-H292 cells.</p> </list-item> <list-item id="o0010"> <label></label> <p id="p0010">Passage number has a significant effect on the response of cells to whole smoke.</p> </list-item> <list-item id="o0015"> <label></label> <p id="p0015">Vapour phase contributes approximately 90% of the cytotoxic effect of whole smoke.</p> </list-item> <list-item id="o0020"> <label></label> <p id="p0020">The cell culture system is able to differentiate between two smoking regimens.</p> </list-item> </list> </p> </sec> </abstract>