Development of an in vitro cytotoxicity model for aerosol exposure using 3D reconstructed human airway tissue; application for assessment of e-cigarette aerosol. Issue 7 (October 2015)

• Record Type: Journal Article
• Authors: Neilson, Louise; Mankus, Courtney; Thorne, David; Jackson, George; DeBay, Jason; Meredith, Clive
• Is Part Of: Toxicology in vitro. Volume 29:Issue 7(2015)
• Page Start: 1952
• Page End: 1962
• Publication Date: 2015-10
• Subjects: Toxicity testing -- In vitro -- Periodicals; Toxicology -- Periodicals; 615.9
• DOI: 10.1016/j.tiv.2015.05.018
• Languages: English
• ISSNs: 0887-2333

Abstract

<abstract xml:lang="en" abstract-type="author-highlights" id="ab005"> <title id="st005">Highlights</title> <sec> <p id="sp0005"> <list id="l0005"> <list-item id="o0005"> <label></label> <p id="p0005">There are currently no standards for the assessment of aerosol emissions <italic>in vitro</italic>.</p> </list-item> <list-item id="o0010"> <label></label> <p id="p0010">There is a need to develop <italic>in vitro</italic> biological techniques for the analysis of aerosols.</p> </list-item> <list-item id="o0015"> <label></label> <p id="p0015">EpiAirway™ tissue model can distinguish between known irritants and non-irritants.</p> </list-item> <list-item id="o0020"> <label></label> <p id="p0020">E-cigarette aerosols showed little to no cytotoxicity compared with cigarette smoke.</p> </list-item> <list-item id="o0025"> <label></label> <p id="p0025">Using an aggressive puffing regime, e-cigarette aerosol showed little cytotoxicity.</p> </list-item> </list> </p> </sec> </abstract>