Disturbance of gene expression in primary human hepatocytes by hepatotoxic pyrrolizidine alkaloids: A whole genome transcriptome analysis. Issue 7 (October 2015)

• Record Type: Journal Article
• Authors: Luckert, Claudia; Hessel, Stefanie; Lenze, Dido; Lampen, Alfonso
• Is Part Of: Toxicology in vitro. Volume 29:Issue 7(2015)
• Page Start: 1669
• Page End: 1682
• Publication Date: 2015-10
• Subjects: Toxicity testing -- In vitro -- Periodicals; Toxicology -- Periodicals; 615.9
• DOI: 10.1016/j.tiv.2015.06.021
• Languages: English
• ISSNs: 0887-2333

Abstract

<abstract xml:lang="en" abstract-type="author-highlights" id="ab005"> <title id="st005">Highlights</title> <sec> <p id="sp0005"> <list id="l0005"> <list-item id="o0005"> <label></label> <p id="p0005">Structurally different PA highly disturb gene expression in primary human hepatocytes.</p> </list-item> <list-item id="o0010"> <label></label> <p id="p0010">PA deregulate numerous phase I and II enzymes as well as transport proteins.</p> </list-item> <list-item id="o0015"> <label></label> <p id="p0015">PA affect cell cycle regulation, cell death and development of cancer.</p> </list-item> <list-item id="o0020"> <label></label> <p id="p0020">PA interfere with lipid metabolism and bile acid flow.</p> </list-item> </list> </p> </sec> </abstract>