Interleukin 35: Critical regulator of immunity and lymphocyte-mediated diseases. Issue 5 (October 2015)

• Record Type: Journal Article
• Authors: Egwuagu, Charles E.; Yu, Cheng-Rong; Sun, Lin; Wang, Renxi
• Is Part Of: Cytokine & growth factor reviews. Volume 26:Issue 5(2015)
• Page Start: 587
• Page End: 593
• Publication Date: 2015-10
• Subjects: Cytokines -- Periodicals; 571.84
• DOI: 10.1016/j.cytogfr.2015.07.013
• Languages: English
• ISSNs: 1359-6101

Abstract

<abstract abstract-type="author-highlights" id="abs0005"> <title id="sect0005">Highlights</title> <sec> <p id="spar0005"> <list id="lis0005"> <list-item id="lsti0005"> <label></label> <p id="par0005">Update on current understanding of the immunebiology of IL-35 and subunits (p35 and Ebi3).</p> </list-item> <list-item id="lsti0010"> <label></label> <p id="par0010">IL-35 induces expansion of lymphocytes into regulatory B (135-Breg) and T (iTR35) cells.</p> </list-item> <list-item id="lsti0015"> <label></label> <p id="par0015">Autologous i35-Breg is effective therapy for experimental uveitis.</p> </list-item> <list-item id="lsti0020"> <label></label> <p id="par0020">IL-35 suppresses experimental autoimmune uveitis and collagen-induced arthritis.</p> </list-item> </list> </p> </sec> </abstract>