Cardiotrophin-like cytokine factor 1 (CLCF1) and neuropoietin (NP) signalling and their roles in development, adulthood, cancer and degenerative disorders. Issue 5 (October 2015) - Sims, Natalie A.
Highlights Signalling complexes formed by CLCF1, CRLF1 and neuropoietin are described. The roles of CLCF1 and CRLF1 in human and murine development are described. CLCF1 and CRLF1 affect kidney and lung pathology, osteoarthritis and haematopoiesis. Potential results of targeting these pathways in human pathology are suggested.