Interleukin-6: Biology, signaling and strategies of blockade. Issue 5 (October 2015)

• Record Type: Journal Article
• Authors: Schaper, Fred; Rose-John, Stefan
• Is Part Of: Cytokine & growth factor reviews. Volume 26:Issue 5(2015)
• Page Start: 475
• Page End: 487
• Publication Date: 2015-10
• Subjects: Cytokines -- Periodicals; 571.84
• DOI: 10.1016/j.cytogfr.2015.07.004
• Languages: English
• ISSNs: 1359-6101

Abstract

<abstract abstract-type="author-highlights" id="abs0005"> <title id="sect0005">Highlights</title> <sec> <p id="spar0005"> <list id="lis0005"> <list-item id="lsti0005"> <label></label> <p id="par0005">IL-6 signals through soluble and membrane-bound IL-6 receptors.</p> </list-item> <list-item id="lsti0010"> <label></label> <p id="par0010">Soluble IL-6 receptor and soluble gp130 buffer IL-6 in the blood.</p> </list-item> <list-item id="lsti0015"> <label></label> <p id="par0015">IL-6 activates JAK and Src kinases.</p> </list-item> <list-item id="lsti0020"> <label></label> <p id="par0020">IL-6 signaling is tighly regulated.</p> </list-item> <list-item id="lsti0025"> <label></label> <p id="par0025">Misregulated IL-6 action causes severe diseases.</p> </list-item> <list-item id="lsti0030"> <label></label> <p id="par0030">Strategies to block IL-6 action.</p> </list-item> </list> </p> </sec> </abstract>