Mutations leading to constitutive active gp130/JAK1/STAT3 pathway. Issue 5 (October 2015)

• Record Type: Journal Article
• Authors: Pilati, Camilla; Zucman-Rossi, Jessica
• Is Part Of: Cytokine & growth factor reviews. Volume 26:Issue 5(2015)
• Page Start: 499
• Page End: 506
• Publication Date: 2015-10
• Subjects: Cytokines -- Periodicals; 571.84
• DOI: 10.1016/j.cytogfr.2015.07.010
• Languages: English
• ISSNs: 1359-6101

Abstract

<abstract abstract-type="author-highlights" id="abs0005"> <title id="sect0005">Highlights</title> <sec> <p id="spar0005"> <list id="lis0005"> <list-item id="lsti0005"> <label></label> <p id="par0005">IHCA show constitutive STAT3 activation caused by somatic mutations in the IL6/JAK/STAT3 pathway.</p> </list-item> <list-item id="lsti0010"> <label></label> <p id="par0010">Recurrent activating mutations of IL6ST, FRK, STAT3, GNAS and JAK1 have been identified in IHCA.</p> </list-item> <list-item id="lsti0015"> <label></label> <p id="par0015">Here we discuss the role of mutated genes in the IL6/JAK/STAT3 pathway in IHCA and other tumors.</p> </list-item> </list> </p> </sec> </abstract>