Comparison of lyophilized versus liquid modified vaccinia Ankara (MVA) formulations and subcutaneous versus intradermal routes of administration in healthy vaccinia-naïve subjects. Issue 39 (22nd September 2015)

• Record Type: Journal Article
• Authors: Frey, Sharon E.; Wald, Anna; Edupuganti, Srilatha; Jackson, Lisa A.; Stapleton, Jack T.; Sahly, Hana El; El-Kamary, Samer S.; Edwards, Kathryn; Keyserling, Harry; Winokur, Patricia; Keitel, Wendy; Hill, Heather; Goll, Johannes B.; Anderson, Edwin L.; Graham, Irene L.; Johnston, Christine; Mulligan, Mark; Rouphael, Nadine; Atmar, Robert; Patel, Shital; Chen, Wilbur; Kotloff, Karen; Creech, C. Buddy; Chaplin, Paul; Belshe, Robert B.
• Is Part Of: Vaccine. Volume 33:Issue 39(2015)
• Page Start: 5225
• Page End: 5234
• Publication Date: 2015-09-22
• Subjects: Vaccines -- Periodicals; 615.372
• DOI: 10.1016/j.vaccine.2015.06.075
• Languages: English
• ISSNs: 0264-410X

Abstract

<abstract abstract-type="author-highlights" id="abs0005"> <title id="sect0005">Highlights</title> <sec> <p id="spar0005"> <list id="lis0005"> <list-item id="lsti0005"> <label></label> <p id="par0005">Lyophilized MVA was more immunogenic than the current liquid formulation of MVA.</p> </list-item> <list-item id="lsti0010"> <label></label> <p id="par0010">The lower ID dose of MVA was immunologically non-inferior to the standard SC dose.</p> </list-item> <list-item id="lsti0015"> <label></label> <p id="par0015">The ID route resulted in more erythema and/or induration than the SC route.</p> </list-item> <list-item id="lsti0020"> <label></label> <p id="par0020">The ID route may increase the number of available doses in an emergency situation.</p> </list-item> </list> </p> </sec> </abstract>