Increase of 25-hydroxyvitamin D levels after initiation of combination antiretroviral therapy. Issue 10 (October 2015)

• Record Type: Journal Article
• Authors: Koga, Ichiro; Seo, Kazunori; Yoshino, Yusuke; Kitazawa, Takatoshi; Ota, Yasuo
• Is Part Of: Journal of infection and chemotherapy. Volume 21:Issue 10(2015:Oct.)
• Page Start: 737
• Page End: 741
• Publication Date: 2015-10
• Subjects: Chemotherapy -- Periodicals; Infection -- Periodicals; Communicable diseases -- Chemotherapy -- Periodicals; 615.5805
• DOI: 10.1016/j.jiac.2015.07.003
• Languages: English
• ISSNs: 1341-321X

Abstract

<abstract xml:lang="en" abstract-type="author" id="abs0010"> <title id="sectitle0010">Abstract</title> <sec> <p id="abspara0010">Although vitamin D deficiency in HIV patients reported worldwide, the mechanisms and the effect of combination antiretroviral therapy (cART) on vitamin D levels are unclear. Patients were 50 male Japanese with HIV who visited Teikyo University Hospital, Tokyo, Japan. Patients were divided into those receiving cART (cART-experienced group, n = 30) and those who had not received cART (cART-naïve group, n = 20). Patients in the cART-experienced group had received treatment with cART for more than one year and those in the cART-naïve group were just about to start cART at study entry. Patients underwent measurement of serum 25-hydroxyvitamin D (25(OH)D) levels and assessment of clinical factors twice at one year intervals.</p> <p id="abspara0015">At study entry, 23 (76.7%) in the cART-experienced group and 19 (95.0%) in the cART-naïve group had vitamin D insufficiency or deficiency. Mean 25(OH)D values were significantly higher in the cART-experienced group (25.2 ng/ml vs. 19.3 ng/ml, <italic>p</italic> = 0.01). However, levels of 25(OH)D at one year increased more in the cART-naïve group (−1.1 ng/ml vs. 5.0 ng/ml, <italic>p</italic> = 0.01), with mean 25(OH)D values in the cART-naïve group increasing to match those in the cART-experienced group. HIV infected patients who initiated cART showed increases in vitamin D levels in one year.</p> </sec> </abstract>