Influence of total genomic alteration and chromosomal fragmentation on response to a combination of azacitidine and lenalidomide in a cohort of patients with very high risk MDS. Issue 10 (October 2015)

• Record Type: Journal Article
• Authors: Ganster, Christina; Shirneshan, Katayoon; Salinas-Riester, Gabriela; Braulke, Friederike; Schanz, Julie; Platzbecker, Uwe; Haase, Detlef
• Is Part Of: Leukemia research. Volume 39:Issue 10(2015:Oct.)
• Page Start: 1079
• Page End: 1087
• Publication Date: 2015-10
• Subjects: Leukemia -- Periodicals; Leukemia -- Periodicals; Leucémie -- Périodiques; Leukemia; Periodicals; Electronic journals; Electronic journals; 616.9941905
• DOI: 10.1016/j.leukres.2015.06.011
• Languages: English
• ISSNs: 0145-2126

Abstract

<abstract abstract-type="author-highlights" id="abs0005"> <title id="sect0005">Highlights</title> <sec> <p id="spar0005"> <list id="lis0005"> <list-item id="lsti0005"> <label></label> <p id="par0005">Molecular karyotyping improves stratification of very high risk MDS/AML patients.</p> </list-item> <list-item id="lsti0010"> <label></label> <p id="par0010">Patients treated by a combination of azacitidine and lenalidomide were analyzed.</p> </list-item> <list-item id="lsti0015"> <label></label> <p id="par0015">The size of total genomic aberrations was a predictive marker for overall survival.</p> </list-item> <list-item id="lsti0020"> <label></label> <p id="par0020">Heavily rearranged chromosomes were associated with molecular <italic>TP53</italic> mutations.</p> </list-item> <list-item id="lsti0025"> <label></label> <p id="par0025">The occurrence of both markers together was associated with therapy refractoriness.</p> </list-item> </list> </p> </sec> </abstract>