The NO-modified HIV protease inhibitor as a valuable drug for hematological malignancies: Role of p70S6K. Issue 10 (October 2015)

• Record Type: Journal Article
• Authors: Maksimovic-Ivanic, Danijela; Mojic, Marija; Bulatovic, Mirna; Radojkovic, Milica; Kuzmanovic, Milos; Ristic, Slobodan; Stosic-Grujicic, Stanislava; Miljkovic, Djordje; Cavalli, Eugenio; Libra, Massimo; Fagone, Paolo; McCubrey, James; Nicoletti, Ferdinando; Mijatovic, Sanja
• Is Part Of: Leukemia research. Volume 39:Issue 10(2015:Oct.)
• Page Start: 1088
• Page End: 1095
• Publication Date: 2015-10
• Subjects: Leukemia -- Periodicals; Leukemia -- Periodicals; Leucémie -- Périodiques; Leukemia; Periodicals; Electronic journals; Electronic journals; 616.9941905
• DOI: 10.1016/j.leukres.2015.06.013
• Languages: English
• ISSNs: 0145-2126

Abstract

<abstract abstract-type="author-highlights" id="abs0005"> <title id="sect0005">Highlights</title> <sec> <p id="spar0005"> <list id="lis0005"> <list-item id="lsti0005"> <label></label> <p id="par0005">Saq-NO exerts more potent anticancer effects on leukemia cell lines than Saq.</p> </list-item> <list-item id="lsti0010"> <label></label> <p id="par0010">Saq-NO exerts antiproliferative effects on Jurkat and Raji cells.</p> </list-item> <list-item id="lsti0015"> <label></label> <p id="par0015">Saq-NO promotes caspase-dependent apoptosis on HL-60 and K652 cells.</p> </list-item> <list-item id="lsti0020"> <label></label> <p id="par0020">Saq-NO is effective on primary acute lymphoblastic and acute myeloid leukemia cells.</p> </list-item> <list-item id="lsti0025"> <label></label> <p id="par0025">p70S6 kinase represents a possible intracellular target for Saq-NO.</p> </list-item> </list> </p> </sec> </abstract>