Frequency of ITPA gene polymorphisms in Iranian patients with acute lymphoblastic leukemia and prediction of its myelosuppressive effects. Issue 10 (October 2015)

• Record Type: Journal Article
• Authors: Azimi, Fatemeh; Mortazavi, Yousef; Alavi, Samin; Khalili, Mitra; Ramazani, Ali
• Is Part Of: Leukemia research. Volume 39:Issue 10(2015:Oct.)
• Page Start: 1048
• Page End: 1054
• Publication Date: 2015-10
• Subjects: Leukemia -- Periodicals; Leukemia -- Periodicals; Leucémie -- Périodiques; Leukemia; Periodicals; Electronic journals; Electronic journals; 616.9941905
• DOI: 10.1016/j.leukres.2015.06.016
• Languages: English
• ISSNs: 0145-2126

Abstract

<abstract abstract-type="author-highlights" id="abs0005"> <title id="sect0005">Highlights</title> <sec> <p id="spar0005"> <list id="lis0005"> <list-item id="lsti0005"> <label></label> <p id="par0005">We identified a novel mutation <italic>IVS3+60G&gt;A</italic> in intron 3 of <italic>ITPA</italic> gene.</p> </list-item> <list-item id="lsti0010"> <label></label> <p id="par0010">The allele frequencies in Iranian population were different from other ethnic groups.</p> </list-item> <list-item id="lsti0015"> <label></label> <p id="par0015">Individuals with aberrant <italic>ITPA</italic> genotype, showed cytotoxic effect after treatment with 6-MP.</p> </list-item> </list> </p> </sec> </abstract>