ID: 135. Issue 1 (November 2015)

• Record Type: Journal Article
• Authors: Tang, Ce; Kamiya, Tomonori; Iwakura, Yoichiro
• Is Part Of: Cytokine. Volume 76:Issue 1(2015)
• Page Start: 91
• Publication Date: 2015-11
• Subjects: Cytokines -- Periodicals; 571.844
• DOI: 10.1016/j.cyto.2015.08.162
• Languages: English
• ISSNs: 1043-4666

Abstract

<abstract xml:lang="en" abstract-type="author" id="ab005"> <title> <x xml:space="preserve">Abstract</x> </title> <sec> <p id="sp005">Dectin-1, the receptor for beta-glucans, protects host from fungal infection. However, the role of Dectin-1 in intestinal immunity has not been elucidated completely. We found that Dectin-1-deficient (Clec7a−/−) mice were refractory to both dextran sodium sulfate (DSS)- and CD45RBhiCD4+ T cell-induced colitis associated with an increase of regulatory T (Treg) cells. The proportion of lactobacilli, especially <italic>Lactobacillus murinus</italic> (<italic>L. murinus</italic>), in commensal microflora was increased in Clec7a−/− mouse colon due to accompanied by a decrease of a group of antimicrobial peptides induced by Dectin-1 signaling. <italic>L. murinus</italic> colonization increased Treg cells in the colon. Oral administration of laminarin, a Dectin-1 antagonist, suppressed the development of DSS-colitis, associated with the increase of <italic>L. murinus</italic> and Treg cells. The proportion of closely related <italic>Lactobacillus</italic> species was decreased in inflammatory bowel disease patients. These observations suggest that Dectin-1 regulates the homeostasis of intestinal immunity by controlling Treg cell differentiation through modification of microbiota.</p> </sec> </abstract>