ID: 213. Issue 1 (November 2015)

• Record Type: Journal Article
• Authors: Mahlakoiv, Tanel; Hernandez, Pedro; Diefenbach, Andreas; Staeheli, Peter
• Is Part Of: Cytokine. Volume 76:Issue 1(2015)
• Page Start: 103
• Publication Date: 2015-11
• Subjects: Cytokines -- Periodicals; 571.844
• DOI: 10.1016/j.cyto.2015.08.217
• Languages: English
• ISSNs: 1043-4666

Abstract

<abstract xml:lang="en" abstract-type="author" id="ab005"> <title> <x xml:space="preserve">Abstract</x> </title> <sec> <p id="sp005">The epithelium is the main entry point for many viruses, but the processes that protect barrier surfaces against viral infections are incompletely understood. Here we identified interleukin 22 (IL-22) produced by innate lymphoid cell group 3 (ILC3) as an amplifier of signaling via interferon-<inline-formula><alternatives><inline-graphic xlink:href="ark:/27927/pgj2n6x7r42" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink" /><mml:math altimg="si1.gif" display="inline" overflow="scroll" id="d13e128" xmlns:mml="http://www.w3.org/1998/Math/MathML"><mml:mrow><mml:mi mathvariant="normal">λ</mml:mi></mml:mrow></mml:math></alternatives></inline-formula> (IFN-<inline-formula><alternatives><inline-graphic xlink:href="ark:/27927/pgj2n6x7rbc" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink" /><mml:math altimg="si2.gif" display="inline" overflow="scroll" id="d13e133" xmlns:mml="http://www.w3.org/1998/Math/MathML"><mml:mrow><mml:mi mathvariant="normal">λ</mml:mi><mml:mo stretchy="false">)</mml:mo></mml:mrow></mml:math></alternatives></inline-formula>, a synergism needed to curtail the replication of rotavirus, the leading cause of childhood gastroenteritis. Cooperation between the receptor for IL-22 and the receptor for IFN-<inline-formula><alternatives><inline-graphic xlink:href="ark:/27927/pgj2n6x7r42" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink" /><mml:math altimg="si1.gif" display="inline" overflow="scroll" id="d13e140" xmlns:mml="http://www.w3.org/1998/Math/MathML"><mml:mrow><mml:mi mathvariant="normal">λ</mml:mi></mml:mrow></mml:math></alternatives></inline-formula>, both of which were 'preferentially' expressed by intestinal epithelial cells (IECs), was required for optimal activation of the transcription factor STAT1 and expression of interferon-stimulated genes (ISGs). These data suggested that epithelial cells are protected against viral replication by co-option of two evolutionarily related cytokine networks. These data may inform the design of novel immunotherapy for viral infections that are sensitive to interferons.</p> </sec> </abstract>