Epstein-Barr virus infection is strictly associated with the metastatic spread of sinonasal squamous-cell carcinomas. Issue 10 (October 2015)

• Record Type: Journal Article
• Authors: Doescher, Johannes; Piontek, Guido; Wirth, Markus; Bettstetter, Marcus; Schlegel, Juergen; Haller, Bernhard; Brockhoff, Gero; Reiter, Rudolf; Pickhard, Anja
• Is Part Of: Oral oncology. Volume 51:Issue 10(2015:Oct.)
• Page Start: 929
• Page End: 934
• Publication Date: 2015-10
• Subjects: Mouth -- Cancer -- Periodicals; Mouth -- Tumors -- Periodicals; Mouth Diseases -- Periodicals; Mouth Neoplasms -- Periodicals; Bouche -- Cancer -- Périodiques; Bouche -- Tumeurs -- Périodiques; Tumeurs -- Périodiques; Electronic journals; 616.9943105
• DOI: 10.1016/j.oraloncology.2015.07.008
• Languages: English
• ISSNs: 1368-8375

Abstract

<abstract xml:lang="en" abstract-type="author-highlights" id="ab005"> <title id="st005">Highlights</title> <sec> <p id="sp0005"> <list id="l0005"> <list-item id="o0005"> <label></label> <p id="p0005">Sinonasal squamous-cell carcinomas (SNSCC) are relatively rare, so the indication for elective neck dissection is difficult.</p> </list-item> <list-item id="o0010"> <label></label> <p id="p0010">TP53 mutations were exclusively associated with shorter survival in SNSCC.</p> </list-item> <list-item id="o0015"> <label></label> <p id="p0015">Other markers like EGFR, KRAS, PIK3CA, BRAF, p16 and HPV had no effect on the metastasis rate and survival.</p> </list-item> <list-item id="o0020"> <label></label> <p id="p0020">Only the EBV positive tumors developed lymph node or distant metastases.</p> </list-item> <list-item id="o0025"> <label></label> <p id="p0025">The presence of EBV is strictly associated with metastasis, so we recommend an elective neck dissection in patients with EBV-positive SNSCC.</p> </list-item> </list> </p> </sec> </abstract>