Methodological challenges in measuring vaccine effectiveness using population cohorts in low resource settings. Issue 38 (11th September 2015)

• Record Type: Journal Article
• Authors: King, C.; Beard, J.; Crampin, A.C.; Costello, A.; Mwansambo, C.; Cunliffe, N.A.; Heyderman, R.S.; French, N.; Bar-Zeev, N.; for the VacSurv Consortium
• Is Part Of: Vaccine. Volume 33:Issue 38(2015)
• Page Start: 4748
• Page End: 4755
• Publication Date: 2015-09-11
• Subjects: Vaccines -- Periodicals; 615.372
• DOI: 10.1016/j.vaccine.2015.07.062
• Languages: English
• ISSNs: 0264-410X

Abstract

<abstract abstract-type="author-highlights" id="abs0005"> <title> <x xml:space="preserve">Abstract</x> </title> <sec> <title id="sect0005">Highlights</title> <p id="spar0031"> <list id="lis0005"> <list-item id="lsti0005"> <label></label> <p id="par0005">We discuss methodological challenges for evaluating vaccine effectiveness using cohorts.</p> </list-item> <list-item id="lsti0010"> <label></label> <p id="par0010">No single set of definitions or analytical approach can address all possible biases.</p> </list-item> <list-item id="lsti0015"> <label></label> <p id="par0015">Careful consideration of denominator, exposure and outcome definitions is needed.</p> </list-item> <list-item id="lsti0020"> <label></label> <p id="par0020">Sensitivity analyses are crucial to examine assumptions and explore subtle relationships.</p> </list-item> </list> </p> </sec> </abstract>