Recombinant H7 hemagglutinin forms subviral particles that protect mice and ferrets from challenge with H7N9 influenza virus. Issue 38 (11th September 2015)

• Record Type: Journal Article
• Authors: Pushko, Peter; Pujanauski, Lindsey M.; Sun, Xiangjie; Pearce, Melissa; Hidajat, Rachmat; Kort, Thomas; Schwartzman, Louis M.; Tretyakova, Irina; Chunqing, Liu; Taubenberger, Jeffery K.; Tumpey, Terrence M.
• Is Part Of: Vaccine. Volume 33:Issue 38(2015)
• Page Start: 4975
• Page End: 4982
• Publication Date: 2015-09-11
• Subjects: Vaccines -- Periodicals; 615.372
• DOI: 10.1016/j.vaccine.2015.07.026
• Languages: English
• ISSNs: 0264-410X

Abstract

<abstract abstract-type="author-highlights" id="abs0005"> <title id="sect0005">Highlights</title> <sec> <p id="spar0005"> <list id="lis0005"> <list-item id="lsti0005"> <label></label> <p id="par0005">Recombinant full-length H7 hemagglutinin (rH7) was expressed in Sf9 cells.</p> </list-item> <list-item id="lsti0010"> <label></label> <p id="par0010">Purified rH7 forms subviral particles (SVP) of approximately 20 nm in diameter.</p> </list-item> <list-item id="lsti0015"> <label></label> <p id="par0015">SVP structures are composed of approximately 3–4 trimers of rH7.</p> </list-item> <list-item id="lsti0020"> <label></label> <p id="par0020">Purified rH7 SVP elicit protective immune response in mice and ferrets.</p> </list-item> </list> </p> </sec> </abstract>