Integrated risk assessment of suicidal ideation and behavior in drug development. Issue 9 (September 2015)

• Record Type: Journal Article
• Authors: Muller, Patrick Y.; Dambach, Donna; Gemzik, Brian; Hartmann, Andreas; Ratcliffe, Sian; Trendelenburg, Christian; Urban, Laszlo
• Is Part Of: Drug discovery today. Volume 20:Issue 9(2015)
• Page Start: 1135
• Page End: 1142
• Publication Date: 2015-09
• Subjects: Drugs -- Design -- Periodicals; Drugs -- Research -- Periodicals; 615.1
• DOI: 10.1016/j.drudis.2015.05.010
• Languages: English
• ISSNs: 1359-6446

Abstract

<abstract abstract-type="author-highlights" id="abs0005"> <title id="sect0005">Highlights</title> <sec> <p id="spar0005"> <list id="lis0005"> <list-item id="lsti0005"> <label></label> <p id="par0005">We provide a brief outline of the clinical landscape and present labeling of compounds with suspected drug-induced suicidal intent and behavior (SIB).</p> </list-item> <list-item id="lsti0010"> <label></label> <p id="par0010">The present regulatory recommendations for prospective assessment of SIB are highlighted.</p> </list-item> <list-item id="lsti0015"> <label></label> <p id="par0015">We discuss the importance of target identification for SIB assessment in the preclinical setting.</p> </list-item> </list> </p> </sec> </abstract>